Genetics of Obesity: Discovery, Biology, Prediction, and Therapeutic Implications.

Authors

Melanie A Babinski, Ruth J F Loos, Sonja I Berndt, Joel N Hirschhorn

Published in

Annual review of medicine. Sep 30, 2026. Epub Sep 30, 2026.

Abstract

With the rise in its prevalence, obesity has become a public health threat worldwide. Understanding the genetic and biological origins of obesity is critical for discovering and implementing better prevention and treatment strategies to combat its dominance and impact on disease risk. This review summarizes current knowledge about the genetic architecture of obesity, including the contribution of rare and common variants to monogenic and polygenic forms of obesity. It discusses the biological underpinnings of discovered genetic loci and how these mechanistic insights may suggest new potential therapeutic drug targets. Lastly, it explores how these genetic discoveries may aid in the prediction of future obesity, particularly in children and young adults, and lead to more effective prevention strategies for obesity and related diseases, including cardiovascular disease, type 2 diabetes, and cancer.

PMID:
42814881
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.