Designing National Programmes for Expanded Carrier Screening: Results from a Discrete-Choice Experiment in Singapore.

Authors

Robin Blythe, Sameera Senanayake, Yasmin Bylstra, Jack Roberts, Christina Choi, Myrabeth Juann Yeo, Jeanette Goh, Nicholas Graves, Ai Ling Koh, Saumya Shekhar Jamuar

Published in

The patient. Sep 30, 2026. Epub Sep 30, 2026.

Abstract

Carrier screening for inherited genetic disorders can reduce the burden of conditions that lead to morbidity and mortality. National carrier screening programme uptake may depend on population preferences for screening. In this study, we aimed to determine how expanded carrier screening in Singapore should be provided based on population stated preferences.
We elicited stated preferences for the design of a national carrier screening programme with seven attributes from 500 Singaporeans aged 18-54 years. A discrete choice experiment was applied using three blocks of ten choice tasks with three alternatives per task, including the choice to opt out of screening. The mixed multinomial logit model was used to analyse preferences. We assessed willingness-to-pay for screening and predicted programme uptake for a range of copayments, and estimated national budget impacts for different programme implementations.
Respondents showed preferences for lower costs, a wider range of diseases included in the panel and shorter wait times. Predicted uptake ranged from 85% [95% confidence interval 83-87] to 90% [88-92] for hypothetical basic and utility-maximising screening programmes, respectively, with no copayments. This declined to 61% [56-66] and 69% [65-73], respectively, for copayments of $1200 per tested couple. Budget impact depended upon policy package, population eligibility, copayments and couples' decision-making processes, but was unlikely to exceed $13.1 m [$11.0-$15.7] per year for a utility-maximising programme unless expanded beyond pre-conception married couples.
There were strong but heterogeneous preferences for expanded carrier screening in the Singaporean general population, with particularly strong preferences for more comprehensive panels of disorders. Accordingly, providing a selection of screening packages may increase programme uptake and support family planning while improving affordability.

PMID:
42814378
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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