Authors
Jiatian Chen, Jinting Zhao, Xiaoxiao Zhang, Huirong Zhu
Published in
Frontiers in pharmacology. Volume 17. Pages 1768252. Epub Jun 12, 2026.
Abstract
Colon cancer (CC) exhibits substantial heterogeneity between right-sided colon cancer (RCC) and left-sided colon cancer (LCC) in terms of embryological origin, molecular characteristics, immune microenvironment, and therapeutic response. Increasing evidence suggests that spatial heterogeneity of the gut microbiota may contribute to these site-specific differences through interactions with local immune, inflammatory, and metabolic microenvironments. Recent studies have also indicated that gut microbiota dysbiosis may participate in the progression, therapeutic response, and microenvironmental remodeling of CC. This review summarizes current evidence regarding the role of gut microbiota spatial heterogeneity in RCC and LCC, with particular emphasis on its potential associations with molecular features, immune regulation, and local metabolic alterations. Furthermore, we discuss recent advances in Traditional Chinese Medicine (TCM)-based interventions targeting the gut microbiota in CC, including potential links between common TCM syndromes, microbial dysbiosis, mucosal barrier dysfunction, and immune-inflammatory alterations. We also summarize the regulatory effects of representative botanical monomers and classical TCM formulas on microbial homeostasis and tumor-related microenvironmental changes. Importantly, this review does not aim to establish fixed correspondences between specific TCM syndromes and tumor location. Instead, gut microbiota heterogeneity may serve as a modern biological reference for understanding site-specific pathogenesis and guiding individualized TCM interventions in CC.
PMID:
42367297
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 14
- Comments 0