Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen.

Authors

Johanna Merlin, Marc Bajénoff

Published in

Trends in immunology. Sep 30, 2026. Epub Sep 30, 2026.

Abstract

Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163^high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dependent circuit that supports marginal metallophilic macrophages.

PMID:
42816191
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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