When Neutrophils Do Not Die: Senescence as a New Axis of Tumor Immunosuppression.

Authors

Lucie Droin, Hannah Garner

Published in

Cancer discovery. Volume 16. Issue 10. Pages 1958-1960. Oct 01, 2026.

Abstract

In this issue of Cancer Discovery, Chen and colleagues leverage single-cell RNA sequencing of neutrophils in the tumor microenvironment of colorectal cancer liver metastases to characterize neutrophil heterogeneity within the metastatic immune landscape. They show that the glucose-deprived metastatic microenvironment drives BHLHE40 upregulation in neutrophils, inducing a senescent tumor-associated neutrophil (TAN) population, TAN1, that actively promotes angiogenesis and excludes CD8+ T cells from the tumor, thereby supporting tumor growth and survival. See related article by Chen et al., p. 2130.

PMID:
42817716
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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