Light-Induced Double Drug Release with Improved Efficiency in Micelles.

Authors

Xuemei Chen, Bryan Liu, Yongqing Yang, Yanmei Li, Hao Chen, Zhaohui Feng, Yuanwei Zhang

Published in

ACS applied bio materials. Oct 01, 2026. Epub Oct 01, 2026.

Abstract

Light-responsive photocages are attractive tools for controlled drug delivery, yet achieving efficient photo-release in aqueous media remains challenging. Herein, a symmetrical BODIPY bis(oxime ester) derivative (BD-diOE) was developed for visible-light-triggered release of valproic acid (VPA). The study confirmed a sequential photo-uncaging process resulting in the release of two equivalents of VPA. To improve aqueous performance, BD-diOE was encapsulated into Pluronic F127 micelles (BD-diOE@F127). Quantitative analysis revealed that BD-diOE@F127 in water releases approximately 30% more VPA than BD-diOE in a methanol-mixed water solvent under identical irradiation conditions. Moreover, BD-diOE@F127 exhibited pronounced light-dependent in vitro cytotoxicity. These results demonstrate that the combination of symmetric molecular design and micelle formulation provides a promising platform for photo-responsive biomaterials and controlled drug delivery applications.

PMID:
42817784
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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