Trends in population attributable risk of Clostridioides difficile infection associated with common outpatient antibiotics in Ontario, Canada, 2017-2024.

Authors

Michelle K Wong, Nick Daneman, Bradley J Langford, Valerie Leung, Kevin L Schwartz, Kevin A Brown

Published in

Infection control and hospital epidemiology. Pages 1-4. Oct 01, 2026. Epub Oct 01, 2026.

Abstract

We evaluated changes in population attributable risk of "4C" antibiotics for community-associated Clostridioides difficile infection in Ontario (2017-2024). Contributions from clindamycin, cephalosporins, and fluoroquinolones declined, whereas amoxicillin-clavulanate increased and became the leading contributor by 2022, highlighting a potential emerging target for outpatient antimicrobial stewardship.

PMID:
42817775
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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