RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1.

Authors

Jiwei Sun, Haoyu Yin, Jian Song, Ning Li, Jie Feng, Xuefeng Lu, Yi Han, Yesen Zhang

Published in

Frontiers in immunology. Volume 17. Pages 1892295. Epub Sep 16, 2026.

Abstract

Nuclear mRNA transport is essential for maintaining mRNA homeostasis and normal cellular functions; however, the mechanisms regulating the nuclear transport of E2F transcription factor 1 (E2F1) mRNA remain poorly understood. In this study, we show that the nuclear RNA transport factor 1 (NXF1) is upregulated in Hemin-treated HT22 cells and intracerebral hemorrhage (ICH) mice, suggesting its involvement in ICH pathogenesis. NXF1 knockdown exerted a protective effect against Hemin-induced inflammatory responses in HT22 cells. Consistently, NXF1 downregulation ameliorated neurological deficits, reduced cell death, and decreased cytokine levels in vivo. Mechanistically, NXF1-mediated neuroprotection was associated with mitophagy induction. Collectively, our findings provide novel insights into ICH progression and identify the RBM15/NXF1/E2F1 axis as a potential target for ICH intervention.

PMID:
42818686
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.

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