Authors
Tiago Reis, J C Alves
Published in
Frontiers in veterinary science. Volume 13. Pages 1851477. Epub Sep 16, 2026.
Abstract
This study aimed to compare the effectiveness of an intradermal mesotherapy protocol, an intra-articular injection of platelet-rich plasma (PRP), and an epidural injection of methylprednisolone in managing degenerative lumbosacral stenosis in dogs.
Retrospective study.
55 dogs.
The animals were divided into three treatment groups: a mesotherapy group (MG, n = 30) treated with a combination of lidocaine, dexamethasone, and midazolam; a PRP group (PRPG, n = 15) treated with epidural PRP; and a methylprednisolone group (MPG, n = 10) treated with epidural methylprednisolone acetate. All treatments consisted of two sessions spaced 15 days apart. Clinical outcomes were measured using the Canine Brief Pain Inventory (CBPI) and Canine Orthopedic Index (COI) before treatment and at 15, 30, 60, 90, and 120 days post-treatment. The Shapiro-Wilk test was used to check for data normality. Group comparisons at each time point were analyzed using the Kruskal-Wallis H test, followed by Dunn's post-hoc test, p < 0.05. Kaplan-Meier estimators were used to create time-to-event probabilities and curves.
All treatments produced clinically significant improvements. The MG and PRPG produced significant improvements in Pain Severity Scores (PSS) and Pain Interference Scores (PIS) scores up to +90d, but only the PRPG maintained these improvements up to +120d (p = 0.03). All groups produced similar results in general gait up to 120 days. No side effects were recorded for any of the treatments.
All three treatments are good options that can be effective, with PRP being the most advantageous, in terms of clinical improvement and duration of effect.
PMID:
42818700
Bibliographic data and abstract were imported from PubMed on 01 Oct 2026.
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