Potential Benefit of Ruxolitinib in Suspected Ocular and Neurological Transplant-Associated Thrombotic Microangiopathy After Allogeneic Stem Cell Transplantation: A Case Report and Review.

Authors

Lise-Marie Pillet, Antoine Arandilla, Gaëtan Sauvetre, Paul Goupillou, Adrien Lefevre, Maximilien Grall, Antoine Bonnevalle, Bertrand Bourre, Dominique Penther, Sophie Porcheron, Fabrice Jardin, Mustafa Alani, Sydney Dubois, Vincent Camus

Published in

Clinical case reports. Volume 14. Issue 10. Pages e73660. Epub Sep 29, 2026.

Abstract

We describe a rare case of suspected delayed-onset TA-TMA with ocular and neurological involvement following allo-HSCT. The condition was refractory to standard therapies; neurological improvement was temporally associated with ruxolitinib initiation, suggesting a possible GVHD overlap. This report supports a multidisciplinary approach to complex post-transplant endothelial injury and supports further investigation of JAK inhibition in selected cases.

PMID:
42819691
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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