Authors
Zahra Bozorgmehr, Janine Peeters, Wout Milis, Laurens A J Rutgeerts, Nezha Badi, Xiaoyu Tan, Cédric Van Goethem, Sareh Rezaei Hosseinabadi, Filip E Du Prez, Guy Koeckelberghs, Ivo F J Vankelecom
Published in
Precision chemistry. Volume 4. Issue 9. Pages 1386-1394. Sep 28, 2026. Epub Apr 03, 2026.
Abstract
Sequence-defined macromolecules (SDMs) offer tremendous promise for critical applications like data storage, optoelectronics, or biomimetics, but their synthesis remains particularly challenging. A generic SDM synthesis strategy is reported now using a support-free orthogonal approach starting from single monomers to produce SDMs. The procedure does not require any support, protection, or deprotection steps, nor does it require solvent switches. Crucially, each reaction step is followed by purification using solvent-resistant nanofiltration to ensure product retention from the reaction mixture with the complete removal of impurities (excess reagents, catalyst, byproducts). The sharp molecular weight resolution of well-tuned epoxy-based membranes renders this strategy highly efficient and versatile, as proven here by applying varying reactions, monomer types, and sizes to prepare two different sequence-defined conjugated macromolecules (SDCMs). Demonstrating the effectiveness of these membrane separations to purify SDCMs across very diverse conditions thus highlights the transformative potential of advanced membrane technology for SDM synthesis. Overall, a robust foundation is provided for advancing SDM development from single monomers to complex, high-purity oligomers.
PMID:
42819494
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 16
- Comments 0