Handles on chromosome architecture.

Authors

Thomas Verin-Debant, Christophe Chapard, Frédéric Beckouët

Published in

Trends in cell biology. Oct 01, 2026. Epub Oct 01, 2026.

Abstract

Cohesin organizes genome folding through loop extrusion, a process regulated by cofactors including NIPBL and PDS5. Recent studies by Wutz et al. and Shah et al. demonstrate that NIPBL promotes loop expansion in mammalian cells, whereas PDS5 restricts loop growth by facilitating NIPBL dissociation from cohesin. Together, these findings reveal a finely tuned mechanism governing genome folding.

PMID:
42823293
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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