Authors
Veeksha V Shetty, Shilpa S Shetty, Vinay Kumar Rajendra, Krishna Sharan, Vadisha Bhat, Harishkumar Madhyastha, Sandeepa Kn
Published in
Oral surgery, oral medicine, oral pathology and oral radiology. Jul 22, 2026. Epub Jul 22, 2026.
Abstract
Inflammation is a hallmark of cancer and plays a critical role in tumour progression and prognosis. This study evaluates systemic blood count-based inflammatory markers in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathological features and personal habits.
This prospective cross-sectional study included patients diagnosed with HNSCC whose clinicopathological data and haematological parameters were collected. The inflammatory ratios calculated included neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), monocyte-to-lymphocyte ratio (MLR) and systemic immune inflammation index (SII).
Higher NLR was significantly associated with haemoglobin (Hb) levels in males (P = .045), tumour stage (P = .037) and nodal stage (P = .015), while elevated MLR correlated with nodal stage (P = .024). Lower LMR was associated with an advanced tumour stage (P = .028). Increased SII showed a significant association with gender (P = .04), Hb levels in males (P = .037) and tumour stage (P = .05).
Elevated NLR, MLR and SII, along with reduced LMR, were significantly associated with advanced tumour and nodal stages in HNSCC. These easily measurable blood-based markers may serve as potential indicators of tumour aggressiveness and aid in early risk stratification of patients.
PMID:
42823232
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.
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