Association between peripheral platelet markers and motoric cognitive risk syndrome: a cross-sectional analysis of data from the WCHAT study.

Authors

Fengjuan Hu, Yan Zhang, Gongchang Zhang, Lixing Zhou, Yiping Deng, Daiping Li, Xueling Deng, Tingting Huang, Chenying Fu, Birong Dong, Meiling Ge

Published in

BMJ open. Volume 16. Issue 10. Pages e115160. Oct 01, 2026. Epub Oct 01, 2026.

Abstract

To investigate the association between peripheral platelet indices and motoric cognitive risk syndrome (MCR).
A cross-sectional analysis using baseline data from the West China Health and Aging Trend (WCHAT) study.
Community settings across several ethnically diverse regions of western China.
From an initial pool of 7536 community-dwelling adults in the WCHAT study, 4080 participants were included in the final analysis after applying exclusion criteria.
The primary outcome was MCR, defined by the concurrent presence of subjective cognitive complaints and slow gait speed (≥1 SD below sex- and age-stratified mean) in the absence of dementia or mobility disability. The exposures were platelet indices, including platelet count (PLT), mean platelet volume, platelet distribution width (PDW), platelet-large cell ratio (P-LCR) and platelet crit (PCT). Multivariable logistic regression was used to examine the associations between platelet indices and MCR. Restricted cubic spline analysis was performed to explore non-linear associations.
Among the 4080 participants, 320 (7.84%) met the diagnostic criteria for MCR. After adjustment for potential confounders, higher PLT (OR=1.17, 95% CI 1.04 to 1.32, p=0.007) and PCT (OR=1.13, 95% CI 1.01 to 1.26, p=0.046) were associated with greater odds of MCR. Conversely, higher PDW (OR=0.85, 95% CI 0.75 to 0.97, p=0.014) and P-LCR (OR=0.87, 95% CI 0.77 to 0.98, p=0.026) were associated with lower odds of MCR. Furthermore, a nonlinear relationship was identified for PDW and MCR (p<0.05), with a threshold at 13.40%.
Specific platelet indices are significantly associated with MCR. Further prospective studies are warranted to confirm these associations and explore the underlying mechanisms.
China Clinical Trial Center (ChiCTR1800018895).

PMID:
42823113
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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