Authors
Kathryn T Shahwan, Lindsey M Voller, Neil K Jairath, Cheng Zheng, William Lotter, Melica Nikahd, Madison Hyer, Emily Ruiz, Allison Vidimos, Fabio Muradás Girardi, David G Brodland, John A Zitelli, Ashley Wysong, David R Carr, Cutaneous Squamous Cell Carcinoma Database Working Group
Published in
Journal of the American Academy of Dermatology. Oct 01, 2026. Epub Oct 01, 2026.
Abstract
The American Joint Committee on Cancer (AJCC8) and Brigham and Women's Hospital are the most commonly used staging systems for cutaneous squamous cell carcinoma (CSCC). Both have limitations.
To develop a novel CSCC staging system (COMPASS-SCC) with improved performance.
This study utilized a retrospective CSCC database from 12 international centers. Univariable and multivariable Fine and Gray models assessed risk factors' impact on major poor outcomes (MPO; metastasis and disease specific death) for inclusion and weight in the staging system. Sensitivity, specificity, positive and negative predictive value (PPV/NPV), Area Under the Receiver Operating Characteristic curve (AUROC), and Uno's c-index were calculated.
20,972 primary tumors were included. Diameter (1 point for ≥2 but <5, 2 points for ≥5 centimeters), depth (1 point for beyond fat or >6 millimeters), differentiation (1 point for moderate, 2 points for poor), large-caliber perineural invasion (1 point), and lymphovascular invasion (1 point) were included in the system, with stages from T1 (0 points) to T4 (≥5 points). Sensitivity, NPV, AUROC, and Uno's c-index were significantly higher in COMPASS-SCC than in AJCC8 and BWH.
Retrospective design.
COMPASS-SCC is a novel CSCC staging system with improved prognostic performance compared to AJCC8 and BWH.
PMID:
42822770
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.
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