Alpha-catenin Mutation-associated Synchronous Follicular Thyroid Carcinoma and Papillary Thyroid Carcinoma With Numerous Adenomatoid Nodules.

Authors

Ran Wang, Q I Zhang, Ruohao Fan, Ying Gao, Samira Kirmiz, Jinping Lai

Published in

Anticancer research. Volume 46. Issue 10. Pages 5775-5779.

Abstract

The relationship between germline catenin alpha 1 (CTNNA1) mutation and thyroid neoplasia remains poorly understood. We report a case with a pathogenic germline CTNNA1 mutation and an unusual constellation of thyroid proliferative lesions.
A 59-year-old woman with a history of invasive ductal carcinoma of the breast was incidentally found to have a thyroid nodule on chest computed tomography (CT). Fine-needle aspiration and repeat biopsies demonstrated multiple follicular-patterned lesions, prompting thyroid lobectomy. Histopathologic examination revealed synchronous minimally invasive follicular thyroid carcinoma (FTC) (2.3 cm) and classic papillary thyroid carcinoma (PTC) (2.5 mm) arising in a background of innumerable adenomatoid nodules diffusely involving thyroid parenchyma. Immunohistochemical studies demonstrated diffuse CK19 positivity with decreased E-cadherin and increased cyclin D1 and p53 expressions in the PTC. Genetic testing identified a pathogenic heterozygous CTNNA1 mutation without evidence of phosphatase and tensin homolog (PTEN) alteration.
This case expands the spectrum of germline CTNNA1-associated disease and raises the possibility that diffuse multifocal thyroid proliferative lesions with thyroid carcinomas may represent an underrecognized manifestation of CTNNA1-related hereditary cancer predisposition.

PMID:
42823177
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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