Authors
Mitsunobu Arizono, Kenei Furukawa, Masashi Tsunematsu, Yuto Yamahata, Hiroshi Nakanishi, Yasuto Futagawa, Michinori Matsumoto, Koichiro Haruki, Haruka Kobayashi, Tomohiko Taniai, Shinji Onda, Koki Iida, Toru Ikegami
Published in
Anticancer research. Volume 46. Issue 10. Pages 5599-5608.
Abstract
The prognostic significance of post-hepatectomy-related disseminated intravascular coagulation (DIC) in patients undergoing hepatic resection for colorectal liver metastases (CRLM) remains unclear.
This single-center retrospective study included 89 patients who underwent hepatic resection for CRLM between December 2003 and March 2024. Post-hepatectomy-related DIC was defined as a revised Japanese Association for Acute Medicine DIC score of 3 or higher on postoperative day 3. Prognostic factors for overall and disease-free survival were analyzed using Cox proportional hazards regression models.
Post-hepatectomy-related DIC occurred in 29 patients (33%). Patients with post-hepatectomy-related DIC were more likely to undergo simultaneous colorectal and liver resection and anatomical hepatectomy, and had larger tumors, longer operative time, greater blood loss, and longer postoperative hospital stay. In multivariable analysis, carcinoembryonic antigen ≥20 ng/ml and post-hepatectomy-related DIC were independently associated with poorer overall survival, whereas lymph node metastasis and extrahepatic disease were independently associated with poorer disease-free survival.
Post-hepatectomy-related DIC was an independent predictor of poorer overall survival after hepatic resection for CRLM and may be useful for postoperative risk stratification.
PMID:
42823165
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 21
- Comments 0