Acute abdominal presentation of mantle cell lymphoma mimicking acute appendicitis: a case report.

Authors

Marena Gray, Ilias Marios Oikonomou, Mohammad Limbada, Stavros Gourgiotis

Published in

Journal of surgical case reports. Volume 2026. Issue 9. Pages rjag856. Epub Sep 30, 2026.

Abstract

Lymphoma presenting as an acute abdomen is rare in adults and is more commonly seen in children, particularly with Burkitt or diffuse large B-cell lymphoma. Approximately 1 per cent of appendicectomy specimens contain neoplasms, with only a very small proportion (~0.015 per cent) representing primary appendiceal lymphomas. A man in his 50s with no prior history of malignancy presented with a two-day history of right iliac fossa pain. Computed tomography demonstrated features consistent with acute appendicitis, without features suggestive of malignancy. A laparoscopic appendicectomy was performed without complication. Histopathological examination confirmed acute transmural appendicitis and mantle cell lymphoma (MCL) involving the appendiceal lymphoid tissue. The lymphoma was non-mass-forming and would likely have remained undetected without routine immunohistochemical analysis. This report describes a rare presentation of previously undiagnosed MCL identified alongside acute appendicitis, highlighting the importance of routine histopathological examination, even when intraoperative and radiological findings are consistent with uncomplicated appendicitis.

PMID:
42820123
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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