Prostatic urethral lift in young men seeking preservation of ejaculatory function and fertility-related parameters: semen analysis up to 18 months and comparative review of MIST.

Authors

Nicola D'Altilia, Silvia Secco, Francesco Guzzi, Anna Ricapito, Marco Finati, Lorenzo Mazzotta, Gian M Busetto, Carlo Bettocchi, Giuseppe Carrieri, Pasquale Annese

Published in

Minerva urology and nephrology. Volume 78. Issue 4. Pages 574-582.

Abstract

Minimally invasive surgical therapies (MIST) aim to relieve lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) while preserving sexual and ejaculatory function. We prospectively assessed semen parameters up to 18 months after prostatic urethral lift (PUL) in men under 50 prioritizing ejaculation and contextualized these findings against other MIST.
In this single-center cohort (N.=20), semen analyses (according to WHO 6^th edition) were performed at baseline, 6, and 18 months after PUL. Functional outcomes were prospectively collected through uroflowmetry with post-void residual (PVR) measurement, and subjective outcomes through the International Prostate Symptom Score (IPSS) questionnaire.
No statistically significant deterioration of semen parameters were observed (median total sperm count at timepoints: 29.5→31.0→30.5 million/mL; P=0.88), as well as for ejaculate volume and pH. Motility, vitality, and morphology remained within reference thresholds. LUTS improved durably (Qmax +67%, PVR -50%, IPSS -60%). Complications and re-treatment rates were 15% (one had prostatitis treated with antibiotic therapy, one patient required a bladder catheter for 7 days due to acute urinary retention) and 10% (one for LUTS e one for calcification of device) respectively. Notably, this series is the first to report two cases of successful paternity following PUL.
In carefully selected young men, PUL did not result in a deterioration of the semen quality and ejaculation through 18 months while providing durable symptom relief. To our knowledge, this is the first report of successful paternity following PUL. Ejaculation-sparing MIST should be central to counseling for fertility-conscious patients.

PMID:
42823867
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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