A superoxide anion-specific chemiluminescent probe for detection of acute inflammation.

Authors

Xin Zhang, Hongyu Wang, Zhensheng Li, Hui Wen, Tingting Sun, Yanlong Liu, Zhigang Xie

Published in

Journal of materials chemistry. B. Oct 02, 2026. Epub Oct 02, 2026.

Abstract

Biomarker-responsive chemiluminescence (CL) probes have been developed as a promising technology for noninvasive bioimaging of diseases. Based on the high sensitivity of CL imaging technology, a boron dipyrromethene (BODIPY)-based CL probe (BDPH₁) with a hydroxypyridine group was designed for the detection of superoxide anion (O₂˙^-). The activation of BDPH₁ is strictly O₂˙^- dependent, and the CL signal persists for longer than 40 h, which is significantly longer than the signal duration of traditional CL probes. Moreover, the CL probe can detect the inflammation in a murine peritonitis model. This study demonstrates that BDPH₁ is more efficient over many existing CL probes in terms of specific selectivity and signal duration.

PMID:
42825540
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.

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