Authors
Ruoyan Miao, Yingzhe Li, Lu Zheng, Manzhang Xu, Mengdi Chen, Yidan Li, Jinqi Hou, Chuan Song, Ziyue Chen, Xuewen Wang, Wei Huang
Published in
Advanced materials (Deerfield Beach, Fla.). Pages e75209. Oct 02, 2026. Epub Oct 02, 2026.
Abstract
Wrinkled microstructures provide an effective strategy for constructing stable and low-noise soft bioelectronic interfaces, yet their large-area, continuous, and controllable fabrication remains challenging. Here, we report a large-area continuous ultrathin micro-wrinkled film that rapidly forms wrinkle microstructures through interfacial stress instability at a rate of 70 µm·s-1. The film exhibits excellent geometric deformability and mechanical compliance, enabling effective relaxation of local stress concentration at dynamic interfaces. Flexible strain sensors based on this microstructure achieve sensitive and rapid responses over a broad strain adaptability, with a detection range from 23 to 2350 µε and a response time as low as 50 ms, allowing stable monitoring of diverse physiological signals, including pulse, respiration, voice, and muscle motion. Furthermore, owing to its good biocompatibility and conformal contact capability, the film can function as a cardiac interface for high-fidelity cardiac mechanical activity acquisition and electrical regulation of arrhythmia. Building on this platform, we further integrated flexible signal acquisition hardware with machine-learning algorithms to establish a skin-brain inspired intelligent sensing system capable of real-time physiological signal analysis and high-accuracy classification. This work provides a general strategy for developing stable and highly biocompatible next-generation bioelectronic interfaces.
PMID:
42825709
Bibliographic data and abstract were imported from PubMed on 02 Oct 2026.
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