Authors
Steven M Blum, Thomas L Chan, Neal P Smith, Courtney Ambrose, Katherine H Xu, Alice Tirard, Nandini Samanta, Sidney Martin, Roya Best, Elizabeth Tuttle, Christopher T Stueber, Yuhui Song, Vaishnavi R Yalala, Haley Barnes, Sean T Bannon, Chloe Simms, Benjamin Y Arnold, Mushriq Al-Jazrawe, Joseph J Zhao, Kamil Slowikowski, Jessica Tantivit, Kasidet Manakongtreecheep, Lukas M Altenburger, Simon Knott, Matthew R Strickland, Michael G Drage, Linda T Nieman, Jesse S Boehm, Raghav Sundar, Gary Reynolds, Samuel J Klempner, Alexandra-Chloé Villani
Published in
Science immunology. Volume 11. Issue 124. Pages eaeb9068. Oct 02, 2026. Epub Oct 02, 2026.
Abstract
Malignant ascites is caused by the peritoneal dissemination of cancer and has a poor prognosis. Here, we performed multiomic analyses on ascites samples from patients with cancer and identified RORC-expressing dendritic cells (RORC DCs) enriched in malignant ascites. RORC DCs expressed PIGR and were transcriptionally similar to murine RORγt+ DCs/Thetis cells implicated in immune tolerance. We devised a high-purity sorting strategy to enable in vitro experiments with patient-derived RORC DCs, which indicated that these cells were phenotypically stable and stimulated T cell proliferation while attenuating IFNG expression. Multiplexed immunofluorescence identified RORC DCs in primary tumors and demonstrated their enrichment in regional lymph node metastases. These results associate human RORC DCs with advanced malignancies and suggest a role for these cells in the tumor microenvironment.
PMID:
42826173
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 84
- Comments 0