Ln-M4B3T-DOTA - a new sterically overcrowded LCT for protein pseudocontact shift NMR spectroscopy.

Authors

Annika Matt, Daniel Häussinger

Published in

Chemical communications (Cambridge, England). Oct 02, 2026. Epub Oct 02, 2026.

Abstract

Paramagnetic lanthanoid chelating tags (LCTs) enable the measurement of long-range structural restraints in biomolecular NMR spectroscopy via pseudocontact shifts and residual dipolar couplings. Herein, we report a new LCT based on the M4-cyclen scaffold bearing leucic acid side arms that yields very large anisotropic susceptibility parameters.

PMID:
42826052
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.

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