Hippo signaling and vestigial-like family member 3 at the stromal-immune interface in autoimmunity.

Authors

Olesya Plazyo, Jake Erba, Allison C Billi, J Michelle Kahlenberg, Johann E Gudjonsson

Published in

Trends in molecular medicine. Oct 02, 2026. Epub Oct 02, 2026.

Abstract

The Hippo pathway, classically recognized for its roles in cell proliferation, survival, and development, is increasingly recognized as an important regulator of tissue-immune communication. Recent studies suggest that Hippo signaling within epithelial and stromal compartments influences inflammatory, interferon, and fibrotic responses that contribute to autoimmune disease pathogenesis. In this review, we discuss emerging evidence linking Hippo signaling to tissue remodeling, innate immunity, and sex-biased autoimmunity, with particular emphasis on the transcriptional cofactor vestigial-like family member 3. We propose that Hippo-dependent regulation of stromal-immune crosstalk may represent a previously underappreciated mechanism contributing to chronic inflammation and fibrosis, and discuss opportunities for therapeutic intervention.

PMID:
42827068
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.

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