Assessment of Acute Functional Effects of Perfluorooctanoic Acid (PFOA), Heptafluorobutyric Acid (HFBA), and Hexafluoropropylene Oxide Dimer Acid (HFPO-DA) in Human iPSC-Derived Cardiomyocytes Using Multielectrode Arrays.

Authors

Min Woo Kim, Myeonghee Lee, Jeong Hwan Park, Seul-Gi Lee, Jeong-Seop Oh, Shinhye Park, Youngin Jeong, Yoonseo Kim, Hyewon Shin, C-Yoon Kim, Hyung Min Chung

Published in

Environmental toxicology and pharmacology. Pages 105184. Oct 02, 2026. Epub Oct 02, 2026.

Abstract

Per- and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants associated with public health risks. The cardiac electrophysiological effects of the representative long-chain PFAS perfluorooctanoic acid (PFOA) and short-chain PFASs such as heptafluorobutyric acid (HFBA) and hexafluoropropylene oxide dimer acid (HFPO-DA) remain insufficiently understood. In this study, the electrophysiological effects of PFASs were evaluated in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) using microelectrode array (MEA) analysis. Exposure to 100μM PFOA increased beat period and field potential duration, while reducing spike amplitude in a concentration-dependent manner without affecting contractility. In contrast, HFBA and HFPO-DA did not cause notable changes in either electrophysiological or contractility parameters. These results suggest that acute PFOA exposure disrupts cardiac electrophysiological function, whereas HFBA and HFPO-DA showed no notable effects within the tested conditions.

PMID:
42826924
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.

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