A layered risk framework for non-benchmark intrahepatic cholangiocarcinoma after curative-intent resection: an international multi-institutional analysis.

Authors

Kizuki Yuza, Odysseas P Chatzipanagiotou, Christian Hobeika, Federico Aucejo, Hugo P Marques, Tom Hugh, Feng Shen, Shishir K Maithel, Bas Groot Koerkamp, Irinel Popescu, Matthew J Weiss, Guillaume Martel, Carlo Pulitano, George Poultsides, Andrea Ruzzenente, Todd W Bauer, Ana Gleisner, Itaru Endo, Timothy M Pawlik

Published in

HPB : the official journal of the International Hepato Pancreato Biliary Association. Sep 19, 2026. Epub Sep 19, 2026.

Abstract

Surgical benchmark (BM) values define attainable perioperative outcomes after curative-intent resection for intrahepatic cholangiocarcinoma (iCCA), yet non-benchmark (non-BM) patients remain poorly characterized. Whether tumor biology refines prognosis beyond BM status remains unclear.
Patients undergoing curative-intent resection for iCCA at international centers (2000-2023) were classified using published BM criteria. Non-BM patients were stratified as surgical-axis only, medical-axis only, or dual-axis. A five-component biology risk score, tumor burden score (TBS), and BM status were evaluated for overall survival (OS).
Among 1794 patients, 1128 (62.9%) were non-BM. Non-BM iCCA met 6 of 11 benchmark cutoffs, although readmission, severe complications, and 90-day mortality exceeded thresholds. Five-year OS differed between BM and non-BM patients (45.4% vs 37.1%; p < 0.001), but not across non-BM axes. Within non-BM, ≥2 biology risk factors were associated with worse OS (aHR 2.29, 95%CI 1.53-3.44). Five-year OS ranged from 52.8% in BM/low-TBS to 29.1% in non-BM/high-TBS. Biology score remained associated with OS across BM status (aHR 1.34 per factor, 95%CI 1.17-1.54).
Non-BM iCCA comprised most resected patients and met several benchmark cutoffs. Surgical and medical axes captured perioperative complexity without refining long-term prognosis, whereas TBS and pathologic biology provided additional oncologic stratification.

PMID:
42827056
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.