Authors
Taylor Sawyer, Michael Narvey, Michelle D Tyler, Ayman Abou Mehrem, Sabine Iben, Cassandra DeMartino, David Tingay, Kate Hodgson, Jae Kim, Heidi Herrick, Jennifer Unrau, Mihai Puia-Dumitrescu, Rebecca Shay, Stephen DeMeo, Michael-Andrew Assaad, Joyce O'Shea, Ivana Brajkovic, Bin Huey Quek, Kristen Glass, Michael Wagner, Katharina Bibl, Jennifer Rumpel, Devin McKissic, Nicole Pouppirt, Paul Wildenhain, Natalie Napolitano, Justine Shults, Joseph Reiter, Elizabeth E Foglia, Akira Nishisaki, National Emergency Airway Registry for Neonates (NEAR4NEOS) investigators
Published in
Journal of perinatology : official journal of the California Perinatal Association. Oct 02, 2026. Epub Oct 02, 2026.
Abstract
Evaluate the association between atropine use during neonatal tracheal intubation (TI) and procedural safety and success.
Retrospective multicenter cohort study of neonatal TIs in the NEAR4NEOS registry (2014-2023). Multivariable logistic regression assessed associations between atropine use and cardiac arrest (primary outcome), along with safety and procedural outcomes, adjusting for confounders.
Atropine was used in 8189 of 13,085 TIs (62.6%). It was not associated with reduced odds of cardiac arrest (aOR 0.52, 95% CI 0.25-1.09). Atropine use was associated with lower odds of severe bradycardia (aOR 0.33, 95% CI 0.26-0.41), but higher odds of oxygen desaturation (aOR 1.35, 95% CI 1.22-1.49) and lower first-attempt success (aOR 0.76, 95% CI 0.69-0.85).
Atropine use during neonatal TI was not associated with reduced cardiac arrest. Although it reduced severe bradycardia, it was associated with increased desaturation and lower first-attempt success, warranting further study.
PMID:
42827095
Bibliographic data and abstract were imported from PubMed on 03 Oct 2026.
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