Challenge of antimicrobial-resistant organisms in neonatal intensive care units: a comprehensive review.

Authors

Sidra Shafique, Reem Donia, Jocelyn A Srigley, Vanessa Paquette, Claire Hamilton, Bonita Lee, Julie Choudhury, Sarah Khan, Ashraf Kharrat, Cynthia Joly, Shikha Gupta-Bhatnagar, Alena Tse-Chang, Joseph Ting

Published in

BMJ paediatrics open. Volume 10. Issue 1. Oct 03, 2026. Epub Oct 03, 2026.

Abstract

The escalation of antibiotic-resistant organisms (AROs) represents a formidable challenge to clinical practice and public health globally. Within the landscape of Gram-positive pathogens, methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci remain the most prevalent threats. Concurrently, the rise of Gram-negative AROs, including multidrug-resistant Escherichia coli, Klebsiella pneumoniae and carbapenem-resistant Enterobacterales, has severely curtailed available therapeutic options. These pathogens are associated with significant morbidity and mortality in neonatal intensive care units, where the combination of immunological immaturity and the requirement for invasive interventions places infants at heightened risk. This narrative review synthesises current evidence regarding the microbiology, evolving epidemiology and preventative strategies for AROs within neonatal healthcare settings.

PMID:
42829214
Bibliographic data and abstract were imported from PubMed on 04 Oct 2026.

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