Authors
Carlos José Sánchez Ovejero, Sergio Luis Lima, Irene Chaves Coira, Alfonso Rey Catena
Published in
Clinical biochemistry. Pages 111211. Oct 03, 2026. Epub Oct 03, 2026.
Abstract
The clinical laboratory is undergoing a paradigm shift toward the integration of liquid chromatography-tandem mass spectrometry(MS) into Total Laboratory Automation workflows. While historically relegated to specialized satellite units due to manual pre-analytical requirements, recent technological advancements have enabled the development of fully automated, 'sample-to-result' MS modules. This review provides an authoritative analysis of the technical integration of systems such as the Roche cobas® i 601 and Shimadzu CLAM-2040 in core laboratories. We examine the role of intelligent middleware and artificial intelligence-assisted algorithms in ensuring standardized data validation and quality control tracking and real-time operational monitoring. Furthermore, we evaluate the clinical impact of this integration on diagnostic accuracy for low-concentration analytes in endocrinology and therapeutic drug monitoring. By transitioning from batch-based processing to continuous automated streams, MS establishes itself as a robust, high-throughput tool for routine clinical diagnostics.
PMID:
42829092
Bibliographic data and abstract were imported from PubMed on 04 Oct 2026.
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