Tumor-to-tumor metastasis of small cell carcinoma of presumed pulmonary origin to a sphenoid ridge meningioma: A diagnostic pitfall in preoperative systemic evaluation.

Authors

Satoru Yabuno, Akito Ikeda, Yutaka Yamauchi, Yuu Takahashi, Shingo Nishihiro, Satoshi Kuramoto, Yasuhiro Ono, Atsuhito Uneda, Tomotsugu Ichikawa

Published in

Surgical neurology international. Volume 17. Pages 525. Epub Sep 18, 2026.

Abstract

Tumor-to-tumor metastasis (TTM) to a meningioma is rare. Atypical meningioma-like lesion with systemic cancer risk factors warrants evaluation for metastatic disease before resection.
An 80-year-old man with a smoking history and pulmonary emphysema presented with progressive cognitive decline. Magnetic resonance imaging showed a rapidly enlarging left sphenoid ridge dural-based mass with heterogeneous enhancement and extensive peritumoral edema. Chest radiography revealed a right upper paramediastinal opacity, but chest computed tomography and systemic staging were not performed before craniotomy. Histopathology demonstrated metastatic small cell carcinoma within a meningothelial meningioma, confirming TTM. Postoperative imaging supported small cell carcinoma of presumed pulmonary origin. Despite radiotherapy and chemotherapy, leptomeningeal dissemination developed, and the patient died 15 months after surgery.
In older smokers with abnormal chest radiograph and atypical meningioma-like lesions, systemic malignancy should be evaluated before resection. When surgery is necessary, the operative goal should prioritize tissue diagnosis and decompression.

PMID:
42829540
Bibliographic data and abstract were imported from PubMed on 04 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.