Authors
Garima Chandak, Bimlesh Kumar, Shubham Kumar, Sumel Ashique, Utpal Bhui, Narendra Kumar Pandey, Biplab Debnath, Fatimah M Al-Salem, Sabina Yasmin, Mohammed Safar M Brady, Md Yousuf Ansari
Published in
iScience. Volume 29. Issue 10. Pages 116658. Oct 16, 2026. Epub Sep 23, 2026.
Abstract
Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal growth and maturation, as well as in maintaining synaptic plasticity. Dysregulated BDNF levels significantly increase the risk of neurological and metabolic disorders. In type 2 diabetes mellitus, several pathological mechanisms, including prolonged hyperglycemia, oxidative damage, chronic inflammation, and impaired insulin sensitivity, are known to drive neurodegenerative processes and deterioration of cognitive function. Impaired BDNF signaling can result in compromised synaptic transmission and gradual loss of neurons, with the hippocampus being particularly vulnerable. A growing body of evidence points to a strong correlation between diminished BDNF levels and diabetes related cognitive decline. Findings from both human clinical trials and animal studies have consistently reported reduced BDNF concentrations in brain tissues and systemic circulation in diabetic conditions. Therapeutic strategies aimed at upregulating BDNF expression and modulating its downstream signaling pathways hold considerable promise for preventing or mitigating diabetes associated cognitive deficits.
PMID:
42831040
Bibliographic data and abstract were imported from PubMed on 05 Oct 2026.
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