Photothermal-driven surface redox reconstruction of Mn³⁺-engineered α-MoO₃/MnO_x nanozyme for triple-negative breast cancer therapy.

Authors

Qin Gao, Yingping Chen, Ke Li, Yanyan Yang, Sixue Zhai, Yiheng Wang, Chuyu Dong, Kexin Wang, Chunhai Luo, Qi Pan

Published in

Journal of materials chemistry. B. Oct 05, 2026. Epub Oct 05, 2026.

Abstract

Triple-negative breast cancer (TNBC) remains a highly aggressive malignancy with limited therapeutic options. Herein, a Mn³⁺-engineered α-MoO₃/MnO_x (MM) nanozyme was developed for synergistic photothermal and chemodynamic therapy of TNBC. The strongly coupled MM heterointerface facilitated efficient electron transfer and enabled photothermal-driven surface redox reconstruction under near-infrared (NIR) irradiation. As a result, MM triggered a self-sustaining Mn³⁺/Mn²⁺ redox cycle, leading to continuous glutathione depletion and reactive oxygen species (ROS) generation. Simultaneously, oxidative dissolution of molybdenum species released molybdate ions that disrupted phosphate metabolism and inhibited ATP synthesis, resulting in metabolic collapse. Through the synergistic effects of redox catastrophe and energy deprivation, MM effectively suppressed TNBC cell proliferation and induced apoptosis. In vivo T₁-weighted magnetic resonance imaging demonstrated efficient tumor accumulation of MM. Furthermore, MM combined with NIR irradiation significantly inhibited tumor growth in 4T1 tumor-bearing mice with favorable biosafety. This work presents a photothermal-responsive Mn³⁺-engineered nanozyme that integrates sustained redox cycling and metabolic disruption, providing a promising strategy for TNBC therapy.

PMID:
42831441
Bibliographic data and abstract were imported from PubMed on 05 Oct 2026.

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