Resmetirom: A New FDA-approved Drug as a Targeted Therapeutic Strategy in Metabolic Dysfunction Associated Steatohepatitis: Translational Evidence from Current Clinical Trials.

Authors

Ghulam Hassam-U-Din Tarrar, Syed Shafaat Hussain, Muhammad Raza Sarfraz, Malka A Hassan, Tushar Kanti Bhadra

Published in

Prague medical report. Volume 127. Issue 3. Pages 145-150.

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) represents a significant global health burden, affecting 3-5% of the population and projected to become a leading cause of liver transplantation by 2030. This review examines Resmetirom, the first FDA-approved drug for non-cirrhotic MASH with moderate to severe hepatic fibrosis. As a selective thyroid hormone receptor beta (THR-β) agonist, Resmetirom enhances hepatic lipid metabolism through increased mitochondrial β-oxidation and improved lipoprotein profiles. Multiple clinical trials have demonstrated its efficacy in reducing hepatic fat content, improving liver histology, and resolving MASH without worsening fibrosis. While generally well-tolerated, gastrointestinal side effects including diarrhea and nausea were more common with Resmetirom than placebo. This breakthrough therapy offers a promising option for MASH management, though long-term studies and broader geographic representation in trials remain necessary to fully establish its role in clinical practice.

PMID:
42831601
Bibliographic data and abstract were imported from PubMed on 05 Oct 2026.

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