Ketene, Diketene, and 1,3-Cyclobutanedione Chemistry - Industrial Relevance, Reactivity, and Emerging Applications of Cyclobutane Motifs.

Authors

Philipp Kohler, Christoph Taeschler, Arne Jan Stepen, Leo Schmid, Ulrich Mayerhoeffer

Published in

Chimia. Volume 80. Issue 9. Pages 617-622. Sep 30, 2026. Epub Sep 30, 2026.

Abstract

Ketene and diketene are cornerstone intermediates of industrial chemistry, enabling synthesis of a wide range of functional products. Beyond their established applications, side products of ketene dimerization provide access to 1,3-cyclobutanedione and triketene chemistry. This review highlights industrial relevance, reactivity, scalable access to 1,3-cyclobutanedione via the dione salt, and emerging applications of cyclobutane motifs in pharmaceuticals, emphasizing opportunities for further derivatization and process development.

PMID:
42831514
Bibliographic data and abstract were imported from PubMed on 05 Oct 2026.

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