Palmitate puts ACLY in shape to reprogram macrophages.

Authors

Bin Huang, Chengqian Yin

Published in

Cell reports. Volume 45. Issue 10. Pages 118061. Oct 05, 2026. Epub Oct 05, 2026.

Abstract

Zhao et al.¹ show that palmitate-driven ATP citrate lyase (ACLY) palmitoylation stabilizes nuclear ACLY tetramers, increases acetyl CoA production, and promotes pro-inflammatory macrophage programs. Targeting macrophage SCD1 with palmitate supplementation exploits this pathway to remodel the tumor microenvironment and suppress hepatocellular carcinoma.

PMID:
42832336
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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