Preparation of Hollow Co-doped ZIF-L-PDA for Synergistic Chemo-Photothermal Biofilm Eradication.

Authors

Guoyang Xie, Jin Huang, Xiaheng Wang, Hengyi Xu

Published in

Analytical biochemistry. Pages 116264. Oct 05, 2026. Epub Oct 05, 2026.

Abstract

Bacterial infections, especially those triggered by bacterial biofilms, remain a thorny challenge in antibacterial treatment. Metal-organic frameworks (MOFs), as carriers of metal ions that can sustainably release antibacterial ingredients, provide a promising alternative strategy for combating bacterial infections. Although the introduction of metal ions into MOFs is a relatively uncomplicated process, it remains an arduous task to eradicate all pathogenic bacteria with a limited dosage. Herein, an economical and efficient hollow Co-doped ZIF-L-PDA (HZIF-L-PDA (Co)) nanomaterial was synthesized via a simple dopamine-mediated self-assembly reaction. The uniform incorporation of Co and Zn in the ZIF-L skeleton and the polymerization of dopamine were completed through a one-pot method, avoiding complexity and harsh synthesis conditions. Due to the abundant metal nodes of ZIF-L and the photothermal and adhesion ability of polydopamine (PDA), HZIF-L-PDA (Co) can adhere to the bacterial surface and rely on its chemical antibacterial action and photothermal effect to exhibit a synergistic antibacterial effect, causing cell membrane rupture and invagination in Escherichia coli O157:H7 (E. coli O157:H7) and Staphylococcus aureus (S. aureus), respectively. Antibacterial experiments displayed that the sterilization rates of HZIF-L-PDA (Co) driven by near-infrared (NIR) light at low concentration (75 μg/mL) against E. coli O157:H7 and S. aureus were 96.9% and 97.3%, respectively. The HZIF-L-PDA (Co) realized favorable eradication against E. coli O157:H7 mature biofilms, while the therapeutic effect against S. aureus biofilms was limited at the tested low concentration. Overall, we proposed an easily fabricated MOF-based nanocomposite that fought pathogenic bacteria through chemical and photothermal effects, promising as an alternative to antibiotics.

PMID:
42833569
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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