EUS Shear Wave Elastography for Assessing Pancreatic Fibrosis: An Exploratory Study of Its Histological Correlation.

Authors

Akiya Nakahata, Yasunobu Yamashita, Fumiyoshi Kojima, Yuto Sugihara, Tomokazu Ishihara, Hiromu Morishita, Takahiro Shishimoto, Yuki Kawaji, Takashi Tamura, Masahiro Itonaga, Reiko Ashida, Shin-Ichi Murata, Keisuke Hanada, Akihiro Takeuchi, Atsushi Shimizu, Manabu Kawai, Masayuki Kitano

Published in

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. Volume 38. Issue 10. Pages e70308.

Abstract

Endoscopic ultrasound shear wave elastography (EUS-SWE) enables quantitative, noninvasive assessment of tissue elasticity. However, the association between EUS-SWE and pancreatic histology remains unclear. This study aimed to investigate the utility of EUS-SWE for predicting pancreatic fibrosis by comparing it with histological findings of resected specimens.
Patients who underwent EUS-SWE before pancreatectomy between October 2019 and October 2024 were retrospectively enrolled. SWE was performed near the surgical resection margin, and shear wave velocity (Vs, m/s) was measured. The number of EUS morphological findings according to the Rosemont classification was obtained. Histological findings were assessed using quantitative analysis and grading analysis. The association between EUS-SWE or the number of EUS morphological findings and histological findings, as well as the diagnostic performance of EUS-SWE and EUS morphological findings for predicting histological fibrosis at predefined fibrosis thresholds (≥ 5%, ≥ 10%, ≥ 15%, and ≥ 20%) was evaluated.
Thirty-four patients were included. Vs correlated significantly with quantitative fibrosis (ρ = 0.73, p < 0.001), but not with fatty infiltration and inflammation. The number of EUS morphological findings correlated only with fibrosis grade (ρ = 0.35, p = 0.041). EUS-SWE had higher diagnostic accuracy than EUS morphological findings for predicting histological fibrosis at all thresholds (91.2%, 88.2%, 82.4%, and 88.2% vs. 55.9%, 67.6%, 55.9%, and 50.0%, respectively).
EUS-SWE may serve as a quantitative, noninvasive method for evaluating pancreatic fibrosis.
UMIN ID: 000058397.

PMID:
42833997
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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