Successful Multidisciplinary Management of Acute-On-Chronic Liver Failure in a Twin Pregnancy Using Artificial Liver Support: A Case Report.

Authors

Pingping Luo, Weixia Chen, Lifei Yu, Lina Wang

Published in

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. Oct 05, 2026. Epub Oct 05, 2026.

Abstract

Acute-on-chronic liver failure (ACLF) in pregnancy is a rare, life-threatening condition with high maternal and fetal mortality.
We report a twin-pregnant patient with ACLF managed by a multidisciplinary team. Interventions included comprehensive medical therapy, seven sessions of artificial liver support (plasma exchange), symptom control, nutritional and psychological care, and prophylactic measures against mother-to-child transmission.
The patient successfully delivered healthy twins. Postdelivery, both infants tested negative for HBsAg and HBV-DNA, confirming effective prevention of vertical transmission. Maternal condition stabilized with treatment.
Multidisciplinary management incorporating artificial liver therapy and tailored obstetric care can achieve favorable maternal and neonatal outcomes in ACLF during twin pregnancy.

PMID:
42833876
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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