A microglial circadian clock sculpts synapses during neurodevelopment.

Authors

Annemarie J Carver, Nicole R Zürcher, Evan A Bordt

Published in

Trends in neurosciences. Sep 22, 2026. Epub Sep 22, 2026.

Abstract

In a recent study, Routh and colleagues demonstrated that the circadian clock regulates microglia-directed synaptic refinement during a critical period of neurodevelopment in mice, in a sex-dependent manner. Loss of the major circadian rhythm regulator, Bmal1, in microglia induced a proinflammatory state and excessive pruning of synapses, primarily in adolescent male mice.

PMID:
42833963
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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