Important Considerations in the Interpretation of Diagnostic Testing in Allergy.

Authors

Annabelle F Rowland, Isson T Tayidi, Gerald B Lee

Published in

Immunology and allergy clinics of North America. Volume 46. Issue 4. Pages 739-750. Epub Aug 05, 2026.

Abstract

The diagnosis of immunoglobulin E (IgE)-mediated allergy is challenging because the presence of allergen sensitization often does not correlate with clinical reactivity. Diagnostic testing is most useful when the clinical history suggests a moderate probability of allergy. Skin test and allergen-specific IgE are first-line tests, and component resolved diagnostics, bead-based epitope assays, and basophil activation tests can improve diagnostic accuracy. Finally, biologics and other therapies can affect testing accuracy and should be taken into consideration when interpreting results.

PMID:
42833751
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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