When and How to Tackle Penicillin Allergy During Pregnancy.

Authors

Victoria T Nguyen, Kashvi Patel, Monica T Kraft

Published in

Immunology and allergy clinics of North America. Volume 46. Issue 4. Pages 671-683. Epub Jul 30, 2026.

Abstract

Pregnant women who report penicillin allergy have higher use of broader-spectrum antibiotics and associated complications, yet few have confirmed allergy when evaluated. Proactive evaluation of penicillin allergy in pregnant patients is encouraged by obstetrical societies, though historically allergy testing during pregnancy has not been widely performed. Numerous recent studies have reported positive outcomes for penicillin allergy testing in pregnancy through oral challenge with or without preceding skin testing for patients with low-risk history with few adverse reactions. Patients with high-risk histories such as anaphylaxis or severe delayed hypersensitivity are not candidates for testing; however, these represent the minority of patients.

PMID:
42833747
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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