Practical Guidance for Systemic Treatment Selection in Pediatric Refractory Atopic Dermatitis.

Authors

Suchita Sampath, Joy Mosser-Goldfarb

Published in

Immunology and allergy clinics of North America. Volume 46. Issue 4. Pages 639-651. Epub Jul 30, 2026.

Abstract

Severe or refractory pediatric atopic dermatitis (AD) requires systemic intervention. While severity was historically quantified using physician-administered tools, recent guidelines emphasize patient-centered impacts like pruritus, sleep disturbance, and special site involvement, which heavily affect development and quality of life. Furthermore, treatment is undergoing a paradigm shift, moving away from traditional, broad immunosuppressants (like methotrexate and cyclosporine) toward novel systemic agents. This article reviews the expanding therapeutic spectrum for managing pediatric refractory AD.

PMID:
42833744
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.