Animal Models for Interventional Oncology Research: Overview and Considerations in the Era of New Approach Methodologies.

Authors

Ron C Gaba, Wali Badar, Kailey M Bell, Tanishka D Bhatt, Olayinka G David, Nusrat Khan, Sneha Mittal, Luke N Redlon Bms, Kyle M Schachtschneider, Lawrence B Schook, Taryi Wint, Lobna Elkhadragy

Published in

Journal of vascular and interventional radiology : JVIR. Pages 109112. Oct 05, 2026. Epub Oct 05, 2026.

Abstract

While translational animal models play a meaningful role in interventional oncology (IO) research, recent attention has focused on new approach methodologies (NAMs) prioritizing human biology-based paradigms. In this narrative review, animal models used in IO research, spanning mouse, rat, woodchuck, rabbit, pig, dog, and non-human primate platforms, are presented. In addition, "next generation" animal models, such as humanized models, genetically defined models, and comorbidity models, are summarized. Subsequently, NAM concepts, including organoids, organ-on-a-chip systems, ex vivo organ preparations, and artificial intelligence and in silico modeling tools, and their potential for advancing IO research, are described. Finally, the complementary value of preclinical models in the NAMs era and model selection are considered.

PMID:
42833616
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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