Authors
Victor Zanetti Drumond, José Alcides Almeida de Arruda, Mariana Villaroel-Dorrego, Leonardo Amaral Dos Reis, Gerhilde Callou Sampaio, Lauren Frenzel Schuch, Carolina Louzada Menna-Barreto, Manoela Domingues Martins, Paula Celeghini Goulart, Guilherme Gomes Souza, Fabrício Tinôco Alvim de Souza, Warley Oliveira Silva, Karina Cordero-Torres, Rolando Morales-Espinosa, René Panico, Gerardo Gilligan, Federico Garola, Carlos Marcelo Cerullo, Nicolás Leonardi, Javier Giménez, Verónica Flück, Ángeles Castrillo, Laura Leguina, Claudia Patricia Peña-Vega, Juan Pablo Rodríguez-Mora, Kallana Mezzomo-Faccin, Ricardo Luiz Cavalcanti de Albuquerque-Junior, Rogério Gondak, Mônica Simões Israel, Pollianna Muniz Alves, Amanda Claudino Gomes, Cassiano Francisco Weege Nonaka, Michel Campos Ribeiro, Elismauro Francisco de Mendonça, Victor Hugo Lopes de Oliveira Moreira, Diego Antônio Costa Arantes, Israel Leal Cavalcante, Eveline Turatti, Roberta Barroso Cavalcante, Giovanna Tacchi, Ana Paula Neutzling Gomes, Karen Müller Bubolz, Adriana Etges, María Natalia González Umpiérrez, Natalia Fernanda Tancredi Cueto, Aurita Verónica Beovide-Cortegoso, Ronell Bologna-Molina, Saray Aranda-Romo, Francisco Javier Tejeda-Nava, Lucas Guimarães Abreu, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita
Published in
Oral diseases. Oct 05, 2026. Epub Oct 05, 2026.
Abstract
Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment-related, and survival features of OSJ in Latin America.
This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models.
A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months.
Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.
PMID:
42834673
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.
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