Authors
Xin Lu, Guixiong Zhang, Yuanqiang Xiao, Lizhu Wang, Xinjian Huang, Yitai Xiao
Published in
Neoplasma. Oct 06, 2026. Epub Oct 06, 2026.
Abstract
We explored the relationships between tissue carcinoembryonic antigen (t-CEA) and serum CEA (s-CEA) and further pursued their association with long-term survival among postoperative colorectal cancer (CRC) patients. All patients underwent determination of s-CEA levels and t-CEA expression. Pearson correlation analysis was performed to quantify the interactions between two variables. Kaplan-Meier survival analysis and time-dependent receiver operating characteristic (ROC) analyses were performed. Prognostic factors were subjected to analysis using multivariable Cox regression to form prognostic nomograms. The results showed the positive rate of t-CEA overexpression recorded at 90.96%. No significant correlation was shown between the two variables. CRC patients with high t-CEA expression revealed a significantly poorer overall survival (OS) and progression-free survival (PFS). In unadjusted Kaplan-Meier survival analyses, elevated s-CEA levels were associated with significantly poorer PFS (p = 0.033) but not OS (p = 0.077). Crucially, multivariable Cox proportional hazards regression confirmed that high t-CEA expression, rather than s-CEA, served as a robust independent prognostic factor for both OS (HR = 2.887, p = 0.017) and PFS (HR = 2.500, p = 0.002). Nomograms comprising t-CEA were constructed with superior utility in predicting the survival probability of CRC patients. To conclude, our study demonstrates the superior prognostic value of t-CEA as an independent prognostic factor for CRC compared to s-CEA.
PMID:
42834664
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.
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