Glucagon-like peptide-1 receptor PET/CT in gastrinomas: a case series demonstrating the precise characterization to guide surgical and medical treatment.

Authors

Junyan Xu, Yun Liang, Jie Chen, Shaoli Song

Published in

EJNMMI reports. Volume 10. Issue 1. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

Gastrinoma is a rare type of neuroendocrine tumor with ectopic secretion of gastrin causing Zollinger-Ellison syndrome (ZES). Accurate localization of gastrinomas and their metastases is important for developing precise treatment strategies. We reported three cases of metastatic gastrinomas evaluated with ⁶⁸Ga-exendin-4 and ⁶⁸Ga-DOTANOC PET/CT. Despite most gastrinomas highly expressing somatostatin receptor (SSTR), these patients showed no or heterogeneous uptake on ⁶⁸Ga-DOTANOC PET/CT, whereas ⁶⁸Ga-exendin-4 PET/CT sensitively detected the primary tumor, lymph node metastasis, liver metastasis, and bone metastasis, facilitating accurate tumor assessment and supporting clinical decision-making. The findings were correlated with enhanced CT and MRI and confirmed the location of the hormone-related tumors. This highlights the potential utility of ⁶⁸Ga-exendin-4 PET/CT as a promising imaging modality for evaluating gastrinomas with no or heterogeneous SSTR expression and guiding precise treatment strategies.

PMID:
42834300
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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