Photochemical C-C bond cleavage in α-haloketones via a pyridinium ylide radical: direct access to esters and amides.

Authors

Anup Barman, Krishnandu Dey, Sovan Dey, Suman Patra, Ram Naresh Yadav, Amit Kumar Paul, Md Firoj Hossain

Published in

Organic & biomolecular chemistry. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

We herein report a sustainable, metal-, photocatalyst-, and oxidant-free photooxidative approach for the C-C bond cleavage of phenacyl halides, enabling the direct synthesis of esters and amides from a broad range of alcohols and amines. In-depth mechanistic and DFT studies support the in situ generation of a pyridinium ylide diradical.

PMID:
42834835
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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