Saccharomyces cerevisiae PA YEAST SC-1 induces IL‑12p70 production in primary human dendritic cells.

Authors

Papawee Saiki, Saori Yamamoto, Tomoki Abe, Node Junichi, Kikuchi Yosuke, Katsutaka Oishi

Published in

Bioscience, biotechnology, and biochemistry. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

A food-grade Saccharomyces cerevisiae extract (PA YEAST SC-1) was evaluated in human dendritic cells. SC‑1 increased interleukin (IL)‑12p40 and IL‑6 expression and induced IL‑12p40, IL‑6, and IL‑12p70 secretion. In contrast, LPS did not induce IL‑12p70, and CpG oligodeoxynucleotide (CpG ODN) induced IL‑12p35 (IL12A) mRNA expression without detectable IL‑12p70. These results indicate a distinct cytokine response pattern associated with IL‑12p70 production.

PMID:
42836552
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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