Association of RSV Vaccination With Clinical Outcomes in Older Adults With Heart Failure: A Propensity-Matched Analysis.

Authors

Allahdad Khan, Muhammad Raffey Shabbir, Jamil Nasrallah, Mahrukh Imtiaz, Harshith Thyagaturu, Marat Fudim, Robert J Mentz, Gregg C Fonarow

Published in

Clinical cardiology. Volume 49. Issue 10. Pages e70488.

Abstract

Respiratory syncytial virus (RSV) is increasingly recognized as a trigger for adverse outcomes in older adults with heart failure (HF). Following FDA approval of RSV vaccines for adults ≥ 60 years in 2023, real-world evidence in HF populations remains limited.
We conducted a multicenter retrospective cohort study using the TriNetX US Collaborative Network. Adults ≥ 60 years with HF were identified and stratified by RSV vaccination status from May 1, 2023, to January 01, 2026. Propensity score matching (1:1) was performed. The primary outcome was all-cause mortality. Secondary outcomes included respiratory failure, healthcare utilization, and cardiovascular events.
After PSM, 777 vaccinated and 777 unvaccinated HF patients were analyzed. All-cause mortality (HR 0.51, 95% CI, 0.33-0.79) and ICU admissions were significantly lower in vaccinated patients (2.7% vs. 5.8%, HR 0.46, 95% CI 0.25-0.86), while healthcare utilization was significantly higher in the vaccinated cohort (HR 1.85, 95% CI 1.65-2.08). No significant differences were observed in respiratory failure (7.3% vs. 9.4%, HR 0.87, 95% CI 0.61-1.23), inpatient or emergency visits (29.9% vs. 35.1%, HR 0.97, 95% CI 0.81-1.16), HF exacerbations, myocardial infarction, or stroke. Age-stratified subgroup analyses (60-75 and 75-90 years) showed consistent findings, with no significant cardiovascular differences and significantly higher healthcare utilization in vaccinated patients across both age groups.
In older adults with HF, RSV vaccination was associated with lower mortality and fewer ICU admissions, without a corresponding reduction in overall inpatient/emergency use or acute-care utilization. These findings are hypothesis-generating and may reflect prevention of severe respiratory illness.

PMID:
42836598
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.