Donor-derived bladder cancer following kidney transplantation.

Authors

Eric A Engels, Sandra Burkett, V Krishnan Ramanujan, Kelly J Yu, Petra Lenz, Aaron M Rozeboom, Gabriel J Starrett

Published in

Urology case reports. Volume 69. Pages 103618. Epub Sep 24, 2026.

Abstract

Kidney transplantation is associated with elevated cancer risk. We report a 75- year-old woman diagnosed with bladder cancer five years after receiving a kidney transplant from a male donor. Whole genome sequencing of this tumor revealed many DNA reads that mapped to the Y chromosome, and fluorescent in situ hybridization identified that 32% of tumor cells had a Y chromosome. These results support a donor origin of this cancer, with the most plausible source being the urothelium of the donor allograft. Sequencing also identified BK polyomavirus, which likely contributed to the development of this cancer.

PMID:
42835464
Bibliographic data and abstract were imported from PubMed on 06 Oct 2026.

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